The primary research goal of our lab is to develop anatomic, spectroscopic and diffusion magnetic resonance (MR) imaging tools to elucidate changes in brain structure, metabolism and connectivity in the presence of disease. Our work is focused on the application of signal processing principles to the development of novel radio frequency (RF) pulses and pulse sequences that maximize the information imparted by MR images. We have developed several techniques to harness the power of high-field MR magnets by overcoming physical and hardware limitations in order to visualize the human brain in unprecedented structural and metabolic detail. Together, these techniques have the potential to drastically improve diagnosis, treatment and monitoring of neurological diseases and disorders as well as advance our understanding of the brain in the normal state.